Applications
One of the premises that CTD based its future success on was the endless (literally) applications available to Cyclodextrin's. Wherever water and water insoluble or immiscible materials need to be brought together, one of the Cyclodextrin's is likely to make it possible and/or more efficiently accomplished.
The following table will give you an idea of the variety of the applications possible.
TABLE 4: Approved & Marketed Drugs Formulated with Cyclodextrins
COMPONENT | TRADE NAME | FORMULATION | INDICATION | COMPANY/ COUNTRY |
---|---|---|---|---|
PGE-1/alpha Cyclodextrin | Prostandin | Intra-arterial infusion | Chronic arterial occlusive disease, etc. | Ono/Japan |
PGE-1/alpha Cyclodextrin | Prostandin 500 | Intra-arterial infusion | Controls hypotension during surgery | Ono/Japan |
PGE-2/beta Cyclodextrin | Prostarmon E | Sublingual tablet | Induction of labor | Ono/Japan |
OP-1206/alpha Cyclodextrin | Opalmon | Tablet | Buerger's disease | Ono/Japan |
Benexate/beta Cyclodextrin | Ulgut | Capsules | Antiulcerant | Teikoku/Japan |
Benexate/beta Cyclodextrin | Lonmiel | Capsules | Antiulcerant | Shionogi/Japan |
Iodine/beta Cyclodextrin | Mena-Gargle | Gargling | Throat disinfectant | Kyushin/Japan |
Dexamethasone Glyteer/beta Cyclodextrin | Glymesason ointment | Ointment | Analgesic, anti-inflammatory | Fujinaga/Japan |
Nitroglycerin/beta Cyclodextrin | Nitropen | Sublingual tablet | Coronary dilator | Nippon Kayaku/Japan |
Cefotiam hexatil hydrochloride/alpha Cyclodextrin | Pansporin T | Tablet | Antibiotic | Takeda/Japan |
Oral Cephalosporin/beta Cyclodextrin | Meiact | Tablet | Antibiotic | Meiji Seika/Japan |
PGE-1/alpha Cyclodextrin | Prostavasin | Intra-arterial | Vasodilator | Schwarz/Germany |
Piroxicam/beta Cyclodextrin | Brexin | Tablet | Analgesic & antiphlogistic | Chiesi/Italy |
Itraconazole/hyroxypropyl beta Cyclodextrin | Sporanox Liquid | Oral liquid | Antifungal | Janssen/Belgium |